Pathology images pending
IgA nephropathy, segmental sclerosis pattern.
Less than 15% of glomeruli are globally sclerotic.
No endo- or extra-capillary proliferation or segmental necrosis is seen. There is mild interstitial fibrosis and tubular atrophy. Mild chronic inflammation accompanies the scarring.
Immunofluorescence: There is granular mesangial and some peripheral capillary loop staining for IgA (2-3+), IgM (trace), C3 (1-2+), fibrin (trace), kappa (1-2+), and lambda (1+). 1+ C3 is seen along tubular basement membranes and in vessels. IgG, C1q and albumin are negative.