Patient is a 35-year-old man, who initially presented to nephrology clinic for foamy urine noted ~3 months prior to current evaluation. Otherwise he felt well, with perhaps some vague malaise. He had no abdominal cramping or pain, no rashes, no joint complaints or other constitutional symptoms.
BP 125/85, HR 65, BMI 24. completely normal exam.
Laboratory and other data:
BUN 15 mg/dl
Creatinine 0.9 mg/dl
ANA, ANCA all negative. C3 and C4 normal
Urine analysis: 1.025, pH6.5, 4+blood, 3+protein.
Lipid casts and free fat, numerous acanthocytes, no cellular casts.
Urine protein to creatinine ratio 5 g/g
Short term follow up:
He was initiated on lisinopril and glucocorticoid therapy with prednisone 1 mg/kg/day. Within a month, he developed labile mood changes.
Protein-to-creatinine ratio initially decreased from 5 g/g to 1.5 g/g, then increased back to 4 g/g with the taper
Now the patient is seen in nephrology clinic for follow up. He feels great, with absolutely no rheumatological or constitutional symptoms. Current medications: Lisinopril 10 mg daily, prednisone 10 mg daily,
Physical exam normal. BP 120/82, BMI 24.
UA: 3+ protein, large blood, numerous acanthocytic red blood cells.
BUN 29, creatinine 1.5,
Urine protein/creatinine ratio 4 g/g.